The UK pilots union says it has been formally notified of proposed redundancies at BA CityFlyer.
The carrier operates British Airways branded flights from London City and Edinburgh airports.
A total of 72 potential pilot redundancies were notified out of 248, mainly at the Scottish airport where BA CityFlyer is proposing ending operations, according to the British Airline Pilots Association.
The carrier also warned that its whole future remained uncertain as its parent company BA, which is cutting as many as 12,000 jobs in the face of the Covid-19 crisis.
Balpa general secretary Brian Strutton said: “CityFlyer had been a successful part of BA so this is yet more shocking and devastating news.
“While the chancellor fanfares his job retention scheme the aviation industry continues to haemorrhage jobs.
“The government is making this crisis worse for aviation by imposing restrictions on flying and forcing airlines into a death spiral.
“Balpa will fight for every job in CityFlyer at London City and Edinburgh airports which rely on this important and efficient airline.”
A BA spokesperson said: “We can’t comment further while we consult with our unions.”