Lake Garda trips are being added by Newmarket Holidays through a summer 2021 charter flights schedule from Teesside airport.
Flights will run to Bergamo with tours also offered to include Portofino, Florence and Tuscany and Lake Como.
Prices start at £899 per person for seven nights plus a £50 early discount for bookings made by October 31.
Tees Valley mayor Ben Houchen said: “It’s great to be able to add these holidays to Italy to our 2021 holiday schedule, which we launched last month with flights to Bulgaria and Majorca.
“The impact of this year’s coronavirus pandemic has meant that people haven’t been able to get away as usual, so we’re focused on making 2021 something special.
“We’re giving those across Teesside, Darlington and Hartlepool – and the wider north-east – even more to look forward to when booking from their local airport.”
Newmarket Holidays head of trade sales Richard Forde said: “We are delighted to be putting on another flight from Teesside offering a range of Italian destinations and tours to our customers, new and returning, from the north-east area.”