Singapore Airlines is to reinstate its Manchester-Houston service from December 1.
The transatlantic link will resume three months after the carrier relaunched flights from Manchester to Singapore.
The Texas city will be served three times a week using an Airbus A350-900 in a three class configuration of 42 business class, 24 premium economy Class and 187 economy.
SIA hopes to gradually increase frequency to pre-pandemic levels.
UK and Ireland general manager Mohamed Rafi Mar said: “We are delighted to resume our Houston flights and offer more travel options to our passengers from the Manchester region, after relaunching our flights to Singapore in the summer.”
Manchester airport managing director Karen Smart added: “It’s great to see Singapore Airlines bring back its Houston service, which pre-pandemic was very popular with our passengers across the north.
“With the US opening up to British passengers from November 8 this route will be well received by the three million people across our catchment area that fly to and from America each year.”
The transatlantic service to Houston started as the airline’s first transatlantic route from the UK.