VisitBritain/VisitEngland is to re-locate from London to Birmingham in new headquarters from April 2024.
The national tourism organisation selected Birmingham due to its strong international and UK transport links and availability of local talent.
Chief executive Patricia Yates said the decision had been made after many months of careful consideration and an office will be maintained in the capital.
She said: “Birmingham has excellent transport links for both our international and Britain based staff and key stakeholders, a broad talent pool and good office space.
“Basing our hub office in Birmingham also brings us closer to our regional stakeholders across England including the West Midlands Growth Company, a local visitor economy partnership, with whom we already have a strong working relationship.
“We have seen other government departments and private sector companies successfully transition their operations to the city.
“We are excited about the opportunities and perspectives that having our headquarters in Birmingham will bring, as we continue our work to drive the economic benefits from tourism across the nations and regions and to support the industry.”
Yates added:“We are currently in negotiations on office space in central Birmingham and will announce the site once confirmed.
“We will keep an office presence in London to maintain our relationships with key government and industry stakeholders.”
Other government departments and bodies which have relocated to the West Midlands include HM Revenue & Customs to Birmingham; Homes England to Coventry; and the Department for Levelling Up, Housing and Communities to Wolverhampton.
Birmingham City Council leader John Cotton said: “Today’s fantastic news further underlines Birmingham’s growing stature as a world class tourist destination.
“This is a warm, friendly city region with award-winning museums and galleries, world class cultural institutions and festivals, major sporting events, family friendly attractions, amazing parks and scenic waterways. We look forward to welcoming VisitBritain/VisitEngland to Birmingham.”