Flights and city breaks to Lisbon are being introduced from September by Jet2 and Jet2holidays.
The Portuguese capital will be served from Manchester and Birmingham airports, each with two flights a week.
Flights from Manchester will run between September 3 and October 29 on Mondays and Fridays.
Birmingham departures will operate from September 30 to October 28 on Thursdays and Sundays.
Winter flights will then be available from November 4 to March 24, 2022, from Manchester and November 1 until March 25 from Birmingham.
Lisbon will also be served throughout summer 2022 from both airports.
Jet2 chief executive Steve Heapy said: “Feedback from customers and independent travel agents is telling us that holidaymakers are wanting to plan and book future getaways this year.
“The start of flights, holidays and city breaks from Manchester and Birmingham airports to the new destination of Lisbon is an example of how we are meeting that demand and giving customers even more choice when it comes to their next getaway.
“With multiple weekly flights available for late-summer, autumn and throughout winter 21/22 and summer 22, it gives customers and independent travel agents all the flexibility to suit their budgets and needs.”