A collection for Cancer Research UK Kids & Teens is being made on board all Flybe flights throughout December.
Donations made by passengers and collected by cabin crew during the month will fund life-saving research to find cures and kinder treatments for children, teens and young adults diagnosed with cancer.
Flybe staff and customers have donated more than £680,000 to Cancer Research UK since 2008.
The airline’s chief sales and marketing officer Amy Valcik said: “Cancer touches so many people, whether personally or through friends and family, and Flybe is proud to be supporting Cancer Research UK again on board our flights.
“Over the last eight years, our passengers and staff have helped to raise a fantastic amount of money to support our charity partner’s exemplary work with the fight against cancer.
“We are sure that this year our passengers will step up again and, through their generosity, help us raise more than ever before.”
Claire Rowney, director of Cancer Research UK Kids & Teens, said: “In the UK, around 1,800 children and 2,400 teens and young adults are diagnosed with cancer each year.
Around three-quarters of children (0-14 year-olds) with cancer now survive beyond ten years and many children cancer survivors have benefited from research funded by Cancer research UK.
“There is still more to be done to bring forward the day that every child survives cancer and we are very thankful for Flybe’s support. We’re encouraging all passengers flying over the festive period to dig deep and donate to a worthwhile cause.”